Relationship of IL-17A and IL-17F genetic variations to cervical cancer risk: a meta-analysis

Biomark Med. 2017 May;11(5):459-471. doi: 10.2217/bmm-2016-0315.

Abstract

Aim: We performed a meta-analysis to determine a more precise relationship of IL-17A and IL-17F polymorphisms with cervical cancer risk.

Materials & methods: PubMed, CNKI and Wan Fang databases were searched for studies on these associations using STATA version 10.0 software.

Results: Five studies were included. The AG and AA genotypes and A allele of IL-17A rs2275913 were correlated with an elevated risk of cervical cancer. The TT genotype and T allele of IL-17A rs3748067 and the CC genotype and C allele of IL-17F rs763780 carried a moderate risk of cervical cancer, when compared with the wild-type genotype.

Conclusion: IL-17A and IL-17F polymorphisms therefore have the potential to act as predictive biomarkers for cervical cancer risk.

Keywords: IL-17A; IL-17F; cervical cancer; meta-analysis; polymorphism; rs2275913; rs3748067; rs763780.

Publication types

  • Meta-Analysis

MeSH terms

  • Female
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Interleukin-17 / genetics*
  • Polymorphism, Genetic*
  • Uterine Cervical Neoplasms / genetics*

Substances

  • IL17A protein, human
  • IL17F protein, human
  • Interleukin-17