Comparative studies of reaction of cobalamin (II) and cobinamide (II) with sulfur dioxide

Ilia A Dereven'kov; Pavel A Ivlev; Cristina Bischin; Denis S Salnikov; Radu Silaghi-Dumitrescu; Sergei V Makarov; Oscar I Koifman

doi:10.1007/s00775-017-1474-z

Comparative studies of reaction of cobalamin (II) and cobinamide (II) with sulfur dioxide

J Biol Inorg Chem. 2017 Aug;22(6):969-975. doi: 10.1007/s00775-017-1474-z. Epub 2017 Jun 15.

Authors

Ilia A Dereven'kov¹, Pavel A Ivlev¹, Cristina Bischin², Denis S Salnikov³, Radu Silaghi-Dumitrescu², Sergei V Makarov¹, Oscar I Koifman¹

Affiliations

¹ Institute of Macroheterocyclic Compounds, Ivanovo State University of Chemistry and Technology, Sheremetevskiy str. 7, 153000, Ivanovo, Russia.
² Department of Chemistry and Chemical Engineering, "Babes-Bolyai" University, Str. Arany Janos Nr. 11, 400028, Cluj-Napoca, Romania.
³ Institute of Macroheterocyclic Compounds, Ivanovo State University of Chemistry and Technology, Sheremetevskiy str. 7, 153000, Ivanovo, Russia. densal@isuct.ru.

PMID: 28620693
DOI: 10.1007/s00775-017-1474-z

Abstract

The kinetics of reactions of cobalamin (II) and cobinamide (II) with sulfur dioxide was studied by UV-visible (UV-vis) spectroscopy. Reaction results in oxidation of Co(II) center and involves two aquated SO₂ moieties. The final product is suggested to be complex Co(III)-S₂O ₄^•- . The absence of corrin ring modifications during the reactions was proved.

Keywords: Cobalamin; Cobinamide; Kinetics; Redox reactions; Sulfur dioxide.

Publication types

Comparative Study

MeSH terms

Cobamides / chemistry*
Kinetics
Sulfur Dioxide / chemistry*
Vitamin B 12 / chemistry*

Substances

Cobamides
Sulfur Dioxide
cobinamide
Vitamin B 12