In this work, we provide a theoretical relationship between the spatial-dependent diffusion coefficient derived in the Fick-Jacobs (FJ) approximation and the macroscopic diffusion coefficient of a membrane that depends on the porosity, tortuosity, and the constriction factors. Based on simple mass conservation arguments under equilibrium as well as in nonequilibrium conditions, we generalize previous expressions for the effective diffusion coefficient of an irregular pore, originally obtained by Festa and d'Agliano for horizontal and periodic pores, and then extended by Bradley for tortuous periodic pores, to the case of pores with arbitrary geometry. Through a formal definition of the constrictivity factor in terms of the geometry of the pore, our results provide very clear physical interpretation of experimental measurements since they link the local properties of the flow with macroscopic quantities of experimental relevance in the design and optimization of porous materials. The macroscopic diffusion coefficient as well as the spatiotemporal evolution of the concentration profiles inside a pore have been recently measured by using pulse field gradient NMR techniques. The advantage of using the FJ approach is that the spatiotemporal concentration profile inside a pore of irregular geometry is directly related to the pore's shape and, therefore, that the macroscopic diffusion coefficient can be obtained by comparing the spatiotemporal concentration profiles from such experiments with those of the theoretical model. Hence, the present study is relevant for the understanding of the transport properties of porous materials where the shape and arrangement of pores can be controlled at will.