The aim of this study was to investigate the relationship between employment status (permanent employment, fixed-term employment, unemployment, other) and perceived health status in a sample of the Italian population. Data was obtained from the European Union Statistics on Income and Living Condition (EU-SILC) study during the period 2009 - 2012. The sample consists of 4,848 individuals, each with a complete record of observations during four years for a total of 19,392 observations. The causal relationship between perceived/self-reported health status and employment status was tested using a global logit model (STATA). Our results confirm a significant association between employment status and perceived health, as well as between perceived health status and economic status. Unemployment that was dependent on an actual lack of work opportunities and not from individual disability was found to be the most significant determinant of perceived health status; a higher educational level produces a better perceived health status.