Abstract
An investigation of the formation of fused- and spiro-β-lactone annulate to γ-lactams has shown that the fused systems are formed preferentially, under standard conditions, but that spiro systems are accessible only when the formation of the fused system is blocked and require careful optimisation of reaction conditions. These systems display both weak antibacterial activity and proteasome inhibition.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Cell Line, Tumor
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Cell Survival / drug effects
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Escherichia coli / drug effects
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Humans
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Lactams / chemistry
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Lactams / pharmacology*
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Lactones / chemistry
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Lactones / pharmacology*
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Microbial Sensitivity Tests
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Molecular Conformation
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Proteasome Endopeptidase Complex / metabolism
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Proteasome Inhibitors / chemical synthesis
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Proteasome Inhibitors / chemistry
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Proteasome Inhibitors / pharmacology*
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Spiro Compounds / chemistry
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Spiro Compounds / pharmacology*
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Lactams
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Lactones
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Proteasome Inhibitors
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Spiro Compounds
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Proteasome Endopeptidase Complex