Abstract
Encapsulation of a physiologically active substance, sanguinarine (SA), by a water soluble carboxylatopillar[6]arene (CP6A), is described. The efficient complexation by CP6A, giving a Ka value of (2.4 ± 0.3) × 105 M-1 in pH 7.4, served to increase the water solubility by 4.3-fold, cause a 2.02 shift in pKa, and enhance the antibacterial activity of SA.
MeSH terms
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Alkaloids / chemistry
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Alkaloids / pharmacology*
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology*
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Benzophenanthridines / chemistry
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Benzophenanthridines / pharmacology*
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Dose-Response Relationship, Drug
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Hydrogen-Ion Concentration
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Isoquinolines / chemistry
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Isoquinolines / pharmacology*
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Macrocyclic Compounds / chemistry
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Macrocyclic Compounds / pharmacology*
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Microbial Sensitivity Tests
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Molecular Structure
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Solubility
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Staphylococcus aureus / drug effects*
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Structure-Activity Relationship
Substances
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Alkaloids
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Anti-Bacterial Agents
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Benzophenanthridines
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Isoquinolines
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Macrocyclic Compounds
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carboxylatopillar(6)arene
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sanguinarine