The Potential Role of BMAA in Neurodegeneration

Neurotox Res. 2018 Jan;33(1):222-226. doi: 10.1007/s12640-017-9752-7. Epub 2017 Jun 13.

Abstract

Neurodegenerative diseases are a major public health issue throughout the world with devastating effects on patients and families. Sporadic forms of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis are generally thought to develop as a consequence of genetic susceptibility and environmental influences. A number of environmental triggers have been identified in association with amyotrophic lateral sclerosis and Parkinson's disease. We discuss the role of β-methylamino-L-alanine in the development of neurodegeneration and the potential importance of this neurotoxin as a risk for neurodegeneration.

Keywords: Alzheimer’s disease; Amyotrophic lateral sclerosis; Neurodegeneration; Parkinson’s disease; β-methylamino-L-alanine.

Publication types

  • Review

MeSH terms

  • Amino Acids, Diamino / toxicity*
  • Animals
  • Cyanobacteria Toxins
  • Gene-Environment Interaction
  • Humans
  • Neurodegenerative Diseases / chemically induced*
  • Neurodegenerative Diseases / genetics*
  • Neurotoxins / toxicity*
  • Risk Factors

Substances

  • Amino Acids, Diamino
  • Cyanobacteria Toxins
  • Neurotoxins
  • beta-N-methylamino-L-alanine