Continuous glucose monitoring following pancreatectomy with islet autotransplantation in children

Pediatr Transplant. 2017 Nov;21(7). doi: 10.1111/petr.12998. Epub 2017 Jun 12.

Abstract

Aim was to determine whether CGM could accurately monitor blood glucose concentration in the immediate postoperative period following pancreatectomy with IAT in children. CGM was used in nine patients undergoing IAT at our institution between April 2015 and September 2016 (eight total pancreatectomy and one subtotal pancreatectomy). MAD and MARD of CGM values compared to time-matched serum blood glucose were calculated during the first 5 days of ICU admission. Goal range was defined as 70-140 mg/dL and out-of-range was >140 mg/dL or <70 mg/dL. Of 89 time-matched measures found, 75% of CGM values were within 15 mg/dL, and 51% were within 10 mg/dL, compared to serum glucose. MAD was 11.6 mg/dL, and MARD was 10.6%. CGM values did not differ from serum glucose (P=.74). By Clarke error grid analysis, 100% of paired values were in clinically acceptable zones. By surveillance error grid analysis, 96% of paired values were within clinically acceptable agreement. CGM is a reliable tool in monitoring glycemic control in the immediate postoperative period following pancreatectomy with IAT in children.

Keywords: euglycemia; mean absolute difference; mean absolute relative difference; pancreatitis.

MeSH terms

  • Adolescent
  • Biomarkers / analysis
  • Blood Glucose / analysis*
  • Blood Glucose / metabolism
  • Child
  • Female
  • Humans
  • Hyperglycemia / blood
  • Hyperglycemia / diagnosis*
  • Hyperglycemia / etiology
  • Hypoglycemia / blood
  • Hypoglycemia / diagnosis*
  • Hypoglycemia / etiology
  • Islets of Langerhans Transplantation* / methods
  • Male
  • Monitoring, Physiologic
  • Pancreatectomy*
  • Postoperative Care / methods*
  • Postoperative Complications / blood
  • Postoperative Complications / diagnosis*
  • Retrospective Studies
  • Transplantation, Autologous

Substances

  • Biomarkers
  • Blood Glucose