Sonodynamic therapy, a treatment developing from photodynamic therapy

Photodiagnosis Photodyn Ther. 2017 Sep:19:159-166. doi: 10.1016/j.pdpdt.2017.06.003. Epub 2017 Jun 10.

Abstract

Sonodynamic therapy (SDT) as a new non-invasive treatment developed from photodynamic (PDT), it can kill tumor cells specifically and selectively. Moreover, recently studies showed SDT has potential to treat solid tumor, leukemia and atherosclerosis, remove proliferative scars and kill pathogenic microorganism. As SDT has an extensive application prospect, SDT has attracted more and more research recently. This thesis aims to be an informative introduction on SDT. With the assistance of related literature from 2012 to 2016, we introduce the progress of SDT research in six aspects: the therapeutic mechanism of SDT, development of the sound sensitizer, exploration of the size and frequency of ultrasonic energy, application of SDT, comparison between SDT and PDT, and current situation and future of SDT.

Keywords: Photodynamic therapy; Photosentsitizer; Proliferative scar; Sonodynamic therapy; Sound sensitizer; Tumor; Ultrasound wave.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Antineoplastic Agents / pharmacology
  • Apoptosis / drug effects
  • Atherosclerosis / drug therapy
  • Dendritic Cells / drug effects
  • Humans
  • Inflammation Mediators / metabolism
  • Keloid / drug therapy
  • Leukemia / drug therapy
  • Macrophages / drug effects
  • Membrane Potential, Mitochondrial / drug effects
  • Nanoparticles
  • Neoplasms / drug therapy*
  • Porphyrins / pharmacology
  • Reactive Oxygen Species / metabolism
  • Ultrasonic Therapy / methods*
  • Xanthones / pharmacology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antineoplastic Agents
  • Inflammation Mediators
  • Porphyrins
  • Reactive Oxygen Species
  • Xanthones