A Sendai virus recombinant vaccine expressing a gene for truncated human metapneumovirus (hMPV) fusion protein protects cotton rats from hMPV challenge

Virology. 2017 Sep:509:60-66. doi: 10.1016/j.virol.2017.05.021. Epub 2017 Jun 9.

Abstract

Human metapneumovirus (hMPV) infections pose a serious health risk to young children, particularly in cases of premature birth. No licensed vaccine exists and there is no standard treatment for hMPV infections apart from supportive hospital care. We describe the production of a Sendai virus (SeV) recombinant that carries a gene for a truncated hMPV fusion (F) protein (SeV-MPV-Ft). The vaccine induces binding and neutralizing antibody responses toward hMPV and protection against challenge with hMPV in a cotton rat system. Results encourage advanced development of SeV-MPV-Ft to prevent the morbidity and mortality caused by hMPV infections in young children.

Keywords: Immunity; Metapneumovirus; Neutralizing antibodies; Recombinant vaccine; Respiratory virus; Sendai virus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Neutralizing / blood
  • Antibodies, Viral / blood
  • Antigens, Viral / genetics
  • Antigens, Viral / immunology*
  • Disease Models, Animal
  • Drug Carriers*
  • Metapneumovirus / genetics
  • Metapneumovirus / immunology*
  • Paramyxoviridae Infections / immunology
  • Paramyxoviridae Infections / prevention & control*
  • Sendai virus / genetics*
  • Sigmodontinae
  • Treatment Outcome
  • Vaccines, Synthetic / administration & dosage
  • Vaccines, Synthetic / genetics
  • Vaccines, Synthetic / immunology
  • Viral Fusion Proteins / genetics
  • Viral Fusion Proteins / immunology*
  • Viral Vaccines / administration & dosage
  • Viral Vaccines / genetics
  • Viral Vaccines / immunology*

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Antigens, Viral
  • Drug Carriers
  • Vaccines, Synthetic
  • Viral Fusion Proteins
  • Viral Vaccines