Association of HIV-1 Gag-Specific IgG Antibodies With Natural Control of HIV-1 Infection in Individuals Not Carrying HLA-B*57: 01 Is Only Observed in Viremic Controllers

J Acquir Immune Defic Syndr. 2017 Nov 1;76(3):e90-e92. doi: 10.1097/QAI.0000000000001477.

Abstract

To expand upon our previous observation that HIV-1 Gag-specific IgG antibodies were highest in HIV controllers not carrying HLA-B*57:01, we analysed these antibodies in a larger cohort of viremic controllers (VCs) or elite controllers (ECs) considering carriage of ‘protective’ HLA-B alleles. HIV-1 p24-specific IgG1 and IgG2 antibodies were higher only in HLA-B*57:01− VCs but there were no differences in ECs. Associations of HIV-1 gp140-specific IgG antibodies with HLA-B*57:01 carriage were inconsistent amongst VCs and ECs.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptive Immunity
  • CD8-Positive T-Lymphocytes / immunology
  • Disease Progression
  • HIV Antibodies / immunology*
  • HIV Infections / immunology*
  • HIV Long-Term Survivors*
  • HIV-1 / genetics
  • HIV-1 / immunology*
  • HLA-B Antigens*
  • Humans
  • Immunoglobulin G / immunology*
  • Lymphocyte Activation
  • RNA, Viral
  • Viral Load / immunology*
  • Virus Replication
  • gag Gene Products, Human Immunodeficiency Virus / immunology*

Substances

  • HIV Antibodies
  • HLA-B Antigens
  • HLA-B*57:01 antigen
  • Immunoglobulin G
  • RNA, Viral
  • gag Gene Products, Human Immunodeficiency Virus