Primate-specific Long Non-coding RNAs and MicroRNAs

Hassaan Mehboob Awan; Abdullah Shah; Farooq Rashid; Ge Shan

doi:10.1016/j.gpb.2017.04.002

Primate-specific Long Non-coding RNAs and MicroRNAs

Genomics Proteomics Bioinformatics. 2017 Jun;15(3):187-195. doi: 10.1016/j.gpb.2017.04.002. Epub 2017 Jun 8.

Authors

Hassaan Mehboob Awan¹, Abdullah Shah¹, Farooq Rashid¹, Ge Shan²

Affiliations

¹ CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
² CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China. Electronic address: shange@ustc.edu.cn.

Abstract

Non-coding RNAs (ncRNAs) are critical regulators of gene expression in essentially all life forms. Long ncRNAs (lncRNAs) and microRNAs (miRNAs) are two important RNA classes possessing regulatory functions. Up to date, many primate-specific ncRNAs have been identified and investigated. Their expression specificity to primate lineage suggests primate-specific roles. It is thus critical to elucidate the biological significance of primate or even human-specific ncRNAs, and to develop potential ncRNA-based therapeutics. Here, we have summarized the studies regarding regulatory roles of some key primate-specific lncRNAs and miRNAs.

Keywords: Evolution; LncRNA; MicroRNA; Non-coding RNA; Primate-specific.

Publication types

Review

MeSH terms

Alu Elements / genetics
Alzheimer Disease / genetics
Alzheimer Disease / pathology
Alzheimer Disease / veterinary
Animals
Depressive Disorder, Major / genetics
Depressive Disorder, Major / pathology
Evolution, Molecular
Gene Expression Regulation
MicroRNAs / genetics
MicroRNAs / metabolism*
Primates
RNA, Long Noncoding / genetics
RNA, Long Noncoding / metabolism*
X Chromosome / genetics

Substances

MicroRNAs
RNA, Long Noncoding