Abstract
This study assessed the in vitro synergy between ceftazidime, aztreonam, and ceftazidime-avibactam against serine and metallo-β-lactamase (MBL)-producing pathogens via the Etest MIC:MIC ratio and Agar-Etest synergy methods. The combination of aztreonam and ceftazidime-avibactam was synergistic against all Enterobacteriaceae. None of the tested combinations were consistently synergistic against IMP-producing P. aeruginosa.
Keywords:
Avibactam; Aztreonam; Carbapenemase; Ceftazidime; Etest; Synergy; beta-Lactamase.
Copyright © 2017 Elsevier Inc. All rights reserved.
MeSH terms
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Anti-Bacterial Agents / therapeutic use
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Azabicyclo Compounds / therapeutic use*
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Aztreonam / therapeutic use*
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Ceftazidime / therapeutic use*
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Drug Combinations
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Drug Synergism
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Enterobacteriaceae / drug effects*
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Enterobacteriaceae / metabolism
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Gram-Negative Bacterial Infections / drug therapy*
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Gram-Negative Bacterial Infections / microbiology
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Humans
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / metabolism
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Serine / metabolism*
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beta-Lactamases / metabolism*
Substances
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Anti-Bacterial Agents
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Azabicyclo Compounds
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Drug Combinations
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avibactam, ceftazidime drug combination
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Serine
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Ceftazidime
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beta-Lactamases
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Aztreonam