A possible role of stem cells in nasal polyposis

Allergy. 2017 Dec;72(12):1868-1873. doi: 10.1111/all.13221. Epub 2017 Jul 3.

Abstract

Since its discovery, the understanding of stem/progenitor cells raised dramatically in the last decade. Their regenerative potential is important to develop new therapeutic applications, but the identification advanced much faster than our understanding of stem/progenitor cells. In nasal polyposis, little is known about stem cells/progenitor cells and their ability. However, the further characterization of stem cells/progenitor cells may provide new treatment options for combating nasal polyposis. This review highlights the knowledge of the current literature about stem cells/progenitor cells in nasal polyposis and how this may be exploited in the development of novel treatment strategies.

Keywords: CRSwNP; chronic rhinosinusitis; nasal polyps; stem cells; tissue regeneration.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Disease Models, Animal
  • Gene Expression Regulation
  • Humans
  • Nasal Polyps / etiology*
  • Nasal Polyps / metabolism*
  • Nasal Polyps / pathology
  • Nasal Polyps / therapy
  • Respiratory Mucosa / cytology
  • Respiratory Mucosa / immunology
  • Respiratory Mucosa / metabolism
  • Signal Transduction
  • Stem Cells / cytology
  • Stem Cells / metabolism*