Abstract
Enabled by nickel catalysis, a mild and general catalytic method for C-alkylation of nitroalkanes with unactivated alkyl iodides is described. Compatible with primary, secondary, and tertiary alkyl iodides; and tolerant of a wide range of functional groups, this method allows rapid access to diverse nitroalkanes.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Alkanes / chemistry*
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Alkylation
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Catalysis
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Hydrocarbons, Iodinated / chemistry*
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Molecular Structure
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Nickel / chemistry*
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Nitro Compounds / chemistry*
Substances
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Alkanes
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Hydrocarbons, Iodinated
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Nitro Compounds
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Nickel