Abstract
Two new gold(i)-BODIPY-imidazole based trackable therapeutic bimetallic complexes have been synthesized and fully characterized. They display strong antiproliferative properties on several types of cancers including colon, breast, and prostate and one of them presents a significant anti-inflammatory effect. Additionally, the two compounds could be visualised in vitro by confocal microscopy in the submicromolar range.
MeSH terms
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Anti-Inflammatory Agents / chemical synthesis
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology*
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Boron Compounds / chemistry*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Coordination Complexes / chemical synthesis
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology*
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Drug Discovery
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Fluorescent Dyes / chemistry
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Gold / chemistry*
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Humans
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Imidazoles / chemistry*
Substances
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4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
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Anti-Inflammatory Agents
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Antineoplastic Agents
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Boron Compounds
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Coordination Complexes
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Fluorescent Dyes
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Imidazoles
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Gold
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imidazole