Predictors of Adherence to Nicotine Replacement Therapy (Nicotine Patch) Among Homeless Persons Enrolled in a Randomized Controlled Trial Targeting Smoking Cessation

O Ojo-Fati; J L Thomas; R I Vogel; O Ogedegbe; G Jean-Louis; K S Okuyemi

Predictors of Adherence to Nicotine Replacement Therapy (Nicotine Patch) Among Homeless Persons Enrolled in a Randomized Controlled Trial Targeting Smoking Cessation

J Fam Med. 2016;3(7):1079. Epub 2016 Sep 6.

Authors

O Ojo-Fati^{1

2}, J L Thomas^{2

3

4}, R I Vogel^{4

5}, O Ogedegbe⁶, G Jean-Louis⁶, K S Okuyemi^{1

2

4}

Affiliations

¹ Department of Family Medicine and Community Health, University of Minnesota, Minneapolis, MN, USA.
² Program in Health Disparities Research, University Of Minnesota, Minneapolis, MN, USA.
³ Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
⁴ Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
⁵ Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, MN, USA.
⁶ Department of Population Health, New York University School of Medicine, New York, NY, USA.

PMID: 28580456
PMCID: PMC5453676

Abstract

Introduction: Adherence to smoking cessation treatment is generally low, especially among socio-economically disadvantaged groups including individuals experiencing homelessness and those with mental illnesses. Despite the high smoking rates in homeless populations (~70%) no study to date has systematically examined predictors of adherence to nicotine replacement therapy (NRT) in this population.

Objective: The aim of this secondary analysis was to identify predictors of adherence to NRT in a smoking cessation trial conducted among homeless smokers.

Methods: Secondary analysis of data from a randomized controlled trial enrolling 430 persons who were homeless and current cigarette smokers. Participants were assigned to one of the two study conditions to enhance smoking cessation: Motivational Interviewing (MI; 6 sessions of MI + 8 weeks of NRT) or Standard Care (Brief advice to quit+ 8 weeks of NRT). The primary outcome for the current analysis was adherence to NRT at end of treatment (8 weeks following randomization). Adherence was defined as a total score of zero on a modified Morisky adherence scale). Demographic and baseline psychosocial, tobacco-related, and substance abuse measures were compared between those who did and did not adhere to NRT.

Results: After adjusting for confounders, smokers who were depressed at baseline (OR=0.58, 95% CI, 0.38-0.87, p=0.01), had lower confidence to quit (OR=1.10, 95% CI, 1.01-1.19, p=0.04), were less motivated to adhere (OR=1.04, 95% CI, 1.00-1.07, p=0.04), and were less likely to be adherent to NRT. Further, age of initial smoking was positively associated with adherence status (OR= 0.83, 95% CI, 0.69-0.99, p=0.04).

Conclusion: These results suggest that smoking cessation programs conducted in this population may target increased adherence to NRT by addressing both depression and motivation to quit.

Trial registration: clinicaltrials.gov: NCT00786149.

Keywords: Adherence; Homeless populations; Nicotine replacement therapy; Patch; Randomized controlled trials; Smoking cessation.

Associated data

ClinicalTrials.gov/NCT00786149

Abstract

Associated data

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