Prediction of long-term clinical outcomes using simple functional exercise performance tests in patients with COPD: a 5-year prospective cohort study

Respir Res. 2017 Jun 2;18(1):112. doi: 10.1186/s12931-017-0598-6.

Abstract

The 1-min sit-to-stand (1-min STS) test and handgrip strength test have been proposed as simple tests of functional exercise performance in chronic obstructive pulmonary disease (COPD) patients. We assessed the long-term (5-year) predictive performance of the 1-min sit-to-stand and handgrip strength tests for mortality, health-related quality of life (HRQoL) and exacerbations in COPD patients. In 409 primary care patients, we found the 1-min STS test to be strongly associated with long-term morality (hazard ratio per 3 more repetitions: 0.81, 95% CI 0.65 to 0.86) and moderately associated with long-term HRQoL. Neither test was associated with exacerbations. Our results suggest that the 1-min STS test may be useful for assessing the health status and long-term prognosis of COPD patients. This study was registered at http://www.clinicaltrials.gov/ (NCT00706602, 25 June 2008).

Keywords: COPD; Exacerbations; HRQoL; Longitudinal; Mortality; Prediction.

Publication types

  • Letter
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cause of Death
  • Disease Progression
  • Exercise Test / methods*
  • Forced Expiratory Volume
  • Hand Strength
  • Humans
  • Longitudinal Studies
  • Lung / physiopathology*
  • Netherlands
  • Posture
  • Predictive Value of Tests
  • Prognosis
  • Proportional Hazards Models
  • Prospective Studies
  • Pulmonary Disease, Chronic Obstructive / diagnosis*
  • Pulmonary Disease, Chronic Obstructive / mortality
  • Pulmonary Disease, Chronic Obstructive / physiopathology
  • Pulmonary Disease, Chronic Obstructive / psychology
  • Quality of Life
  • Risk Factors
  • Severity of Illness Index
  • Switzerland
  • Time Factors

Associated data

  • ClinicalTrials.gov/NCT00706602