Biologic Approaches to Problems of the Hand and Wrist

Murphy M Steiner; James H Calandruccio

doi:10.1016/j.ocl.2017.03.010

Biologic Approaches to Problems of the Hand and Wrist

Orthop Clin North Am. 2017 Jul;48(3):343-349. doi: 10.1016/j.ocl.2017.03.010. Epub 2017 Apr 7.

Authors

Murphy M Steiner¹, James H Calandruccio²

Affiliations

¹ Department of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee-Campbell Clinic, 1211 Union Avenue, Suite 510, Memphis, TN 38104, USA. Electronic address: murphysteiner@gmail.com.
² Department of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee-Campbell Clinic, 1211 Union Avenue, Suite 510, Memphis, TN 38104, USA.

PMID: 28577783
DOI: 10.1016/j.ocl.2017.03.010

Abstract

Orthobiologics are not used as frequently in the hand and wrist as in other sites. The most frequently reported is the use of bone morphogenetic protein for the treatment of Kienböck disease. Animal studies have described improved tendon healing with the use of platelet-rich plasma (PRP), but no clinical studies have confirmed these results. PRP has been reported to produce improvements in the outcomes of distal radial fractures and osteoarthritis of the trapeziometacarpal in small numbers of patients. The use of orthobiologics in the hand and wrist are promising, but clinical trials are necessary to establish efficacy and safety.

Keywords: BMP; Hand; Kienböck disease; Orthobiologics; PRP; Wrist.

Publication types

Review

MeSH terms

Biological Therapy* / instrumentation
Biological Therapy* / methods
Bone Morphogenetic Proteins / pharmacology*
Fracture Healing / physiology*
Hand Injuries* / physiopathology
Hand Injuries* / therapy
Humans
Orthopedics / methods
Platelet-Rich Plasma*
Wrist Injuries* / physiopathology
Wrist Injuries* / therapy

Substances

Bone Morphogenetic Proteins