Synthesis and characterization of Eu(III) complexes of modified d-glucosamine and poly(N-isopropylacrylamide)

Guihua Cui; Yu Bai; Wenliang Li; Zhengguo Gao; Shuiying Chen; Nannan Qiu; Toshifumi Satoh; Toyoji Kakuchi; Qian Duan

doi:10.1016/j.msec.2017.03.059

Synthesis and characterization of Eu(III) complexes of modified d-glucosamine and poly(N-isopropylacrylamide)

Mater Sci Eng C Mater Biol Appl. 2017 Sep 1:78:603-608. doi: 10.1016/j.msec.2017.03.059. Epub 2017 Mar 9.

Authors

Guihua Cui¹, Yu Bai², Wenliang Li³, Zhengguo Gao⁴, Shuiying Chen⁵, Nannan Qiu⁵, Toshifumi Satoh⁶, Toyoji Kakuchi⁵, Qian Duan⁷

Affiliations

¹ School of Pharmacy, Jilin Medical University, Jilin 132013, China; Department of Materials Science and Engineering, Changchun University of Science and Technology, Changchun, Jilin 130022, China.
² School of Pharmacy, Jilin Medical University, Jilin 132013, China.
³ School of Pharmacy, Jilin Medical University, Jilin 132013, China; Key Laboratory of Preparation and Application of Environmental Friendly Materials, Ministry of Education, Jilin Normal University, Changchun 130103, China. Electronic address: wenliangl@ciac.ac.cn.
⁴ Chemical and Engineering College, Yantai University, Yantai, Shandong 264005, China.
⁵ Department of Materials Science and Engineering, Changchun University of Science and Technology, Changchun, Jilin 130022, China.
⁶ Division of Biotechnology and Macromolecular Chemistry, Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan.
⁷ Department of Materials Science and Engineering, Changchun University of Science and Technology, Changchun, Jilin 130022, China. Electronic address: duanqian88@hotmail.com.

PMID: 28576028
DOI: 10.1016/j.msec.2017.03.059

Abstract

A series of chain-end functional polymers composed of poly(N-isopropylacrylamide) (PNIPAM) and 2-amino-2-deoxy-d-glucopyranose(d-glucosamine, GA) was synthesized via atom transfer radical polymerization (ATRP). Novel fluorescent complexes of glucosamine-PNI- PAM/Eu(III) were then formed by chelation of the polymers and europium(III) ions. The aqueous solutions of the polymers and its Eu(III) complexes exhibited a lower critical solution temperatures (LCSTs), and which were approximately equal to body temperature. Cell viability assays suggested that these thermosensitive polymers and Eu(III) complexes showed excellent biocompatibility in vitro.

Keywords: Atom transfer radical polymerization (ATRP); Fluorescence; Lower critical solution temperature (LCST); Poly(N-isopropylacrylamide) (PNIPAM); d-glucosamine(GA).

MeSH terms

Acrylamides
Acrylic Resins
Europium
Glucosamine / chemistry*
Temperature

Substances

Acrylamides
Acrylic Resins
poly-N-isopropylacrylamide
Europium
Glucosamine