SUMO Teams Up with a Translocase to Save TOPO

Nalini Dhingra; Xiaolan Zhao

doi:10.1016/j.molcel.2017.05.013

SUMO Teams Up with a Translocase to Save TOPO

Mol Cell. 2017 Jun 1;66(5):577-578. doi: 10.1016/j.molcel.2017.05.013.

Authors

Nalini Dhingra¹, Xiaolan Zhao²

Affiliations

¹ Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
² Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: zhaox1@mskcc.org.

PMID: 28575654
DOI: 10.1016/j.molcel.2017.05.013

Abstract

In this issue of Molecular Cell, Wei et al. (2017) report how a DNA translocase uses SUMO as a cue to save Top2 from ubiquitin-mediated degradation and to minimize DNA breaks, thus providing insights into the SUMO and ubiquitin interplay in genome maintenance.

Keywords: STUbL; genome stability; sumoylation; topoisomerase.

MeSH terms

Humans
Organophosphorus Compounds
SUMO-1 Protein / genetics*
Sumoylation*

Substances

Organophosphorus Compounds
SUMO-1 Protein
trioctyl phosphine oxide