Managing varicella zoster virus contact and infection in patients on anti-rheumatic therapy

Rheumatology (Oxford). 2018 Apr 1;57(4):596-605. doi: 10.1093/rheumatology/kex189.

Abstract

Chickenpox and shingles can be more severe and occasionally life threatening in immunosuppressed patients. As such, some groups warrant a more detailed history, serological testing and consideration of prophylaxis following contact with the virus. Active disease may also require more aggressive treatment with antivirals. Guidance for the use of varicella zoster immunoglobulin has recently been updated by Public Health England with important implications for rheumatology patients.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Antibodies, Viral / immunology*
  • Antirheumatic Agents / therapeutic use*
  • Antiviral Agents / therapeutic use*
  • Child, Preschool
  • Female
  • Herpesvirus 3, Human / immunology*
  • Humans
  • Immunocompromised Host*
  • Rheumatic Diseases* / complications
  • Rheumatic Diseases* / drug therapy
  • Rheumatic Diseases* / immunology
  • Risk Factors
  • Varicella Zoster Virus Infection* / drug therapy
  • Varicella Zoster Virus Infection* / transmission
  • Varicella Zoster Virus Infection* / virology

Substances

  • Antibodies, Viral
  • Antirheumatic Agents
  • Antiviral Agents