Fetal programming and eating disorder risk

J Theor Biol. 2017 Sep 7:428:26-33. doi: 10.1016/j.jtbi.2017.05.028. Epub 2017 May 29.

Abstract

Fetal programming describes the process by which environmental stimuli impact fetal development to influence disease development later in life. Our analysis summarizes evidence for the role of fetal programming in eating disorder etiology through review of studies demonstrating specific obstetric complications and later eating risk of anorexia or bulimia. Using Pubmed, we found thirteen studies investigating obstetric factors and eating disorder risk published between 1999 and 2016. We then discuss modifiable maternal risk factors, including nutrition and stress, that influence anorexia or bulimia risk of their offspring. Translation of these findings applies to preventative strategies by health organizations and physicians to provide optimal health for mothers and their children to prevent development of medical and psychiatric illnesses.

Keywords: Anorexia; Bulimia; Fetal development; Prenatal.

Publication types

  • Review

MeSH terms

  • Feeding and Eating Disorders / epidemiology*
  • Feeding and Eating Disorders / etiology*
  • Feeding and Eating Disorders / psychology
  • Female
  • Fetal Development*
  • Humans
  • Pregnancy
  • Pregnancy Complications / epidemiology
  • Pregnancy Outcome
  • Risk Factors
  • Stress, Psychological / epidemiology