C18-Diterpenoid alkaloids from Delphinium anthriscifolium var. majus

Lian-Hai Shan; Ji-Fa Zhang; Feng Gao; Shuai Huang; Xian-Li Zhou

doi:10.1080/10286020.2017.1335309

C₁₈-Diterpenoid alkaloids from Delphinium anthriscifolium var. majus

J Asian Nat Prod Res. 2018 May;20(5):423-430. doi: 10.1080/10286020.2017.1335309. Epub 2017 Jun 1.

Authors

Lian-Hai Shan^{1

2}, Ji-Fa Zhang¹, Feng Gao¹, Shuai Huang¹, Xian-Li Zhou^{1

2}

Affiliations

¹ a School of Life Science and Engineering, Southwest Jiaotong University , Chengdu 610031 , China.
² b Key Laboratory of Advanced Technology of Materials , Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University , Chengdu 610031 , China.

PMID: 28569094
DOI: 10.1080/10286020.2017.1335309

Abstract

Five new C₁₈-diterpenoid alkaloids, anthriscifoltines C-G (1-5), along with four known diterpenoid alkaloids anthriscifolcines C-F (6-9), were isolated from the extract of Delphinium anthriscifolium var. majus. Their structures were elucidated by extensive spectroscopic analyses (including 1D-, 2D-NMR, and HR-ESI-MS). Compounds 1-5 were also evaluated for their cytotoxic activity against MCF-7, HepG2, and H460 human cancer cell lines.

Keywords: C18-diterpenoid alkaloids; Delphinium; Ranunculaceae; anthriscifolium; cytotoxicity.

MeSH terms

Alkaloids / chemistry*
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / pharmacology
Cell Line, Tumor
Cell Survival / drug effects
Delphinium / chemistry*
Diterpenes / chemistry*
Humans
Magnetic Resonance Spectroscopy

Substances

Alkaloids
Antineoplastic Agents, Phytogenic
Diterpenes