Urinary F2-isoprostanes and the risk of hypertension

Ann Epidemiol. 2017 Jun;27(6):391-396. doi: 10.1016/j.annepidem.2017.05.005. Epub 2017 May 17.

Abstract

Purpose: There is strong biological plausibility for a causal role of reactive oxygen species in vascular pathology but no direct epidemiological evidence linking elevated reactive oxygen species levels to hypertension development. We examined cross-sectional and prospective associations between oxidative status (urinary F2-isoprostanes) and hypertension in the Insulin Resistance Atherosclerosis Study cohort (n = 831).

Methods: The cohort included non-Hispanic white, Hispanic, and non-Hispanic black individuals, with 252 (30%) having prevalent hypertension and 579 participants normotensive at baseline, 122 (21%) of whom developed hypertension during the 5-year follow-up. Four urinary F2-isoprostane isomers were quantified in baseline specimens using LC/MS-MS and were summarized as a composite index. Examined outcomes included hypertension status (yes/no), systolic (SBP) and diastolic blood pressure (DBP), pulse pressure (PP), and mean arterial pressure (MAP).

Results: Prevalent and incident hypertension were associated with greater age, Black race, impaired glucose tolerance, and greater BMI. F2-IsoP levels were lower among men and among non-Hispanic Blacks, were inversely associated with age, and were directly associated with BMI. No cross-sectional association was found between F2-isoprostanes and hypertension status (OR = 0.93, 0.77-0.12). Among the continuous measures of blood pressure only PP was associated with F2-isoprostanes at baseline (beta-coefficient = 0.99, 0.11-1.86). No prospective association was found between F2-isoprostanes and incident hypertension: OR = 0.98, 0.77-1.25. No prospective associations were found for systolic blood pressure and diastolic blood pressure, and pulse pressure. Mean arterial pressure showed an inverse association (beta-coefficient = -0.16, -0.31 to -0.01).

Conclusions: Elevated F2-isoprostane levels do not increase the risk of hypertension.

Keywords: Cohort study; Epidemiology; F(2)-isoprostanes; Hypertension; Oxidative stress.

MeSH terms

  • Adult
  • Black or African American / statistics & numerical data
  • Blood Pressure / physiology
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / urine*
  • F2-Isoprostanes / urine*
  • Female
  • Hispanic or Latino / statistics & numerical data
  • Humans
  • Hypertension / complications
  • Hypertension / epidemiology*
  • Incidence
  • Insulin Resistance*
  • Lipid Peroxidation
  • Male
  • Middle Aged
  • Oxidative Stress / physiology*
  • Prospective Studies
  • Risk Factors
  • United States / epidemiology
  • White People / statistics & numerical data

Substances

  • F2-Isoprostanes