Microbiological diagnosis of biofilm-related infections
Enferm Infecc Microbiol Clin (Engl Ed). 2018 Jun-Jul;36(6):375-381.
doi: 10.1016/j.eimc.2017.04.006.
Epub 2017 May 27.
[Article in
English,
Spanish]
Affiliations
- 1 Servicio de Microbiología, Hospital Universitario Son Espases, Instituto de Investigación Sanitaria de Palma (IdISPa) y Red Española de Investigación en Patología Infecciosa-REIPI. Electronic address: mariad.macia@ssib.es.
- 2 Área de Enfermedades Infecciosas, Servicio de Microbiología, Laboratorio de Biofilms Microbianos, Clínica Universidad de Navarra.
- 3 Servicio de Microbiología, Hospital Universitario Ramón y Cajal e Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS (Madrid) y Red Española de Investigación en Patología Infecciosa-REIPI.
- 4 Servicio de Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Gregorio Marañón y CIBER de Enfermedades Respiratorias (CIBERES CB06/06/0058), Madrid.
Abstract
Biofilm-related infections represent a serious health problem, accounting for 65- 80% of all infections. The infections are generally chronic and characterized by the persistence of the microorganism, due to the increased resistance of biofilms to both the immune system and antimicrobials. Biofilms can be located to almost every human body tissue and on exogenous devices such as catheters, pacemakers, prosthetic material, implants, urinary catheters, etc. Traditional antimicrobial susceptibility studies in clinical microbiology laboratories have lied on the study of planktonic form of microorganisms. However, this approach might lead to miss the biofilm characteristics and to a treatment failure. Microbiological diagnosis and antimicrobial susceptibility studies of biofilm-related infections are complex and, nowadays, represent a challenge that clinicians and microbiologists have to address as a team in the absence of consensus or standardized protocols.
Keywords:
Antimicrobial susceptibility studies on biofilms; Biofilms; Biopelículas; Diagnóstico microbiológico en infecciones por biopelículas; Microbiological diagnosis of biofilm-related infections; Sensibilidad antibiótica en biopelículas.
Copyright © 2017 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.
MeSH terms
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Bacterial Infections / diagnosis*
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Bacterial Infections / etiology
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Bacterial Infections / microbiology
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Biofilms*
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Biopsy
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Catheter-Related Infections / diagnosis
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Catheter-Related Infections / etiology
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Catheter-Related Infections / microbiology
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Disease Susceptibility
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Drug Resistance, Microbial
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Foreign Bodies
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Humans
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Pneumonia, Ventilator-Associated / diagnosis
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Pneumonia, Ventilator-Associated / etiology
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Pneumonia, Ventilator-Associated / microbiology
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Prostheses and Implants / adverse effects
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Prosthesis-Related Infections / diagnosis
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Prosthesis-Related Infections / etiology
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Prosthesis-Related Infections / microbiology
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Specimen Handling
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Surgical Wound Infection / diagnosis
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Surgical Wound Infection / etiology
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Surgical Wound Infection / microbiology