Blood-brain barrier peptide shuttles

Macarena Sánchez-Navarro; Ernest Giralt; Meritxell Teixidó

doi:10.1016/j.cbpa.2017.04.019

Blood-brain barrier peptide shuttles

Curr Opin Chem Biol. 2017 Jun:38:134-140. doi: 10.1016/j.cbpa.2017.04.019. Epub 2017 May 27.

Authors

Macarena Sánchez-Navarro¹, Ernest Giralt², Meritxell Teixidó³

Affiliations

¹ Institute for Research in Biomedicine-Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain.
² Institute for Research in Biomedicine-Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain; Department of Organic Chemistry, University of Barcelona, Spain.
³ Institute for Research in Biomedicine-Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain. Electronic address: meritxell.teixido@irbbarcelona.org.

PMID: 28558293
DOI: 10.1016/j.cbpa.2017.04.019

Abstract

Brain delivery is hampered by the presence of the blood-brain barrier (BBB), a natural defence of the brain that protects it and allows the entrance of nutrients by several mechanisms. Taking advantage of these mechanisms is an opportunity to treat brain related diseases. Among the different alternatives, BBB peptide shuttles are gaining attention to increase brain delivery of therapeutics. The most recent advances in the field are analysed here.

Publication types

Review

MeSH terms

Animals
Biological Transport
Blood-Brain Barrier / metabolism*
Humans
Peptides / metabolism*

Substances

Peptides