Amyloidosis Cutis Dyschromica, a Rare Cause of Hyperpigmentation: A New Case and Literature Review

Pediatrics. 2017 May;139(5):e20160170. doi: 10.1542/peds.2016-0170.

Abstract

Amyloidosis cutis dyschromica is a rare form of primary cutaneous amyloidosis without systemic involvement and characterized by asymptomatic, progressive hyper- and hypopigmentation. We present the first case of a patient with amyloidosis cutis dyschromica diagnosed previously elsewhere as having Addison disease with generalized hyperpigmentation of the skin. This case suggests that in patients presenting with asymptomatic cutaneous dyschromia a skin biopsy for histopathological examination should be considered.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Amyloidosis, Familial / diagnosis*
  • Child
  • Diagnosis, Differential
  • Humans
  • Hyperpigmentation / etiology*
  • Male
  • Skin / pathology*
  • Skin Diseases, Genetic / diagnosis*

Supplementary concepts

  • Amyloidosis, Primary Cutaneous