Enabling Fast Pseudo-2D NMR Spectral Acquisition for Broadband Homonuclear Decoupling: The EXACT NMR Approach

Ikenna E Ndukwe; Alexandra Shchukina; Vadim Zorin; Carlos Cobas; Krzysztof Kazimierczuk; Craig P Butts

doi:10.1002/cphc.201700474

Enabling Fast Pseudo-2D NMR Spectral Acquisition for Broadband Homonuclear Decoupling: The EXACT NMR Approach

Chemphyschem. 2017 Aug 5;18(15):2081-2087. doi: 10.1002/cphc.201700474. Epub 2017 Jun 8.

Authors

Ikenna E Ndukwe^{1

2}, Alexandra Shchukina^{3

4}, Vadim Zorin⁵, Carlos Cobas⁵, Krzysztof Kazimierczuk³, Craig P Butts¹

Affiliations

¹ Department of Chemistry, University of Bristol, Cantocks Close, Bristol., BS8 1TS, UK.
² Department of Pure and Industrial Chemistry, Abia State University, Uturu, PMB 2000., Abia State, Nigeria.
³ Centre of New Technologies, University of Warsaw, Banacha 2C, 02089, Warszawa, Poland.
⁴ Institute for Spectroscopy, Russian Academy of Sciences, Fizicheskaya 5, 142190, Moscow, Troitsk, Russia.
⁵ Mestrelab Research S.L., Feliciano Barrera 9B-Bajo, 15706, Santiago de Compostela, Spain.

PMID: 28557356
DOI: 10.1002/cphc.201700474

Abstract

Pseudo-2D NMR spectroscopy provides a means of acquiring broadband homonuclear decoupled spectra useful for structural characterization of complex molecules. However, data points concatenated in the direct dimension in these experiments are acquired over incremented time periods-leading to long acquisition times with no sensitivity benefits due to the absence of signal averaging between scans. Herein, the concept of EXACT NMR spectroscopy ("burst" non-uniform sampling of data points) is explored in pseudo-2D experiments with results revealing little or no loss in spectral quality or signal intensity despite the acceleration of acquisition-up to 400 % in some cases.

Keywords: EXACT; homonuclear decoupling; non-uniform sampling; pseudo-2D NMR spectroscopy; pure shift.