Abstract
We report a pH-responsive photothermal ablation agent (pH-PTT) based on cyanine dyes for photothermal therapy (PTT). The nanoparticles formed by BSA and pH-PTT preferentially accumulated in the Golgi apparatus of cancer cells compared to normal cells, and thus can be specifically activated by the acidic Golgi apparatus in cancer cells for effective PTT both ex vivo and in vivo.
MeSH terms
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Carbocyanines / chemistry*
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Carbocyanines / pharmacology
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Cell Line
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Cell Survival / drug effects
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Coloring Agents / chemistry*
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Coloring Agents / pharmacology
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Golgi Apparatus / chemistry
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Golgi Apparatus / drug effects
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Golgi Apparatus / metabolism*
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Hep G2 Cells
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Humans
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Hydrogen-Ion Concentration
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Nanoparticles / chemistry
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Neoplasms / drug therapy*
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Neoplasms / pathology*
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Optical Imaging
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Photochemical Processes*
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Phototherapy
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Temperature*
Substances
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Carbocyanines
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Coloring Agents