[Recent development of hypertension and acute renal failure in a 59-year-old woman]

Internist (Berl). 2017 Dec;58(12):1319-1323. doi: 10.1007/s00108-017-0269-1.
[Article in German]

Abstract

We report on a 59-year-old woman who presented with nausea, fatigue, arterial hypertension, and acute renal failure. Clinical examination, laboratory findings of blood and urine and abdominal sonography were inconclusive. Renal biopsy revealed infiltration by a diffuse large B‑cell lymphoma. In fluorodeoxyglucose positron emission tomography/computed tomography tracer enrichment was demonstrated in both kidneys, skeletal system and retroperitoneal lymph nodes. Renal function improved already after the first cycle of R‑CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone). After chemotherapy, a complete remission, normalization of blood pressure and renal function were achieved.

Keywords: Lymphoma, kidney; Lymphoma, large B‑cell, diffuse; Positron-emission tomography, fluorodeoxyglucose; Tomography, x‑ray computed.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / etiology*
  • Antibodies, Monoclonal, Murine-Derived / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biopsy
  • Bone and Bones / pathology
  • Cyclophosphamide / therapeutic use
  • Diagnosis, Differential
  • Doxorubicin / therapeutic use
  • Fatigue / etiology
  • Female
  • Humans
  • Hypertension / etiology*
  • Kidney / pathology
  • Lymph Nodes / pathology
  • Lymphoma, Large B-Cell, Diffuse / diagnosis*
  • Lymphoma, Large B-Cell, Diffuse / drug therapy
  • Middle Aged
  • Nausea / etiology
  • Positron Emission Tomography Computed Tomography
  • Prednisone / therapeutic use
  • Rituximab
  • Vincristine / therapeutic use

Substances

  • Antibodies, Monoclonal, Murine-Derived
  • R-CHOP protocol
  • Rituximab
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone