Analysis of Factors for Predicting Survival in Soft-tissue Sarcoma with Metastatic Disease at Initial Presentation

Anticancer Res. 2017 Jun;37(6):3137-3141. doi: 10.21873/anticanres.11671.

Abstract

Background/aim: We aimed to confirm predictors of survival in soft-tissue sarcoma (STS) patients with metastatic disease at initial presentation in 9 Institutions under the Tokai Musculoskeletal Oncology Consortium.

Patients and methods: Between 2008 and 2013, 47 STS patients with metastatic disease at initial presentation were referred for treatment. The mean follow-up duration was 24 months.

Results: The mean C-reactive protein (CRP) levels were 2.47 mg/dl. The mean hemoglobin and albumin levels were 13.1 g/dl and 4.1 g/dl, respectively. Hemoglobin and albumin levels were significantly correlated with CRP levels. In the multivariate analysis, age, CRP levels, and albumin levels were confirmed as independent prognostic factors for disease-specific survival (DSS).

Conclusion: We suggest that the measurements of CRP and albumin levels are a useful method of identifying STS patients with metastasis at initial presentation that have poor prognosis.

Keywords: C-reactive protein; Soft tissue sarcoma; albumin; metastasis.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / blood*
  • C-Reactive Protein / analysis*
  • Chi-Square Distribution
  • Female
  • Humans
  • Japan
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Predictive Value of Tests
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Factors
  • Sarcoma / blood*
  • Sarcoma / mortality
  • Sarcoma / secondary*
  • Sarcoma / therapy
  • Serum Albumin / analysis*
  • Serum Albumin, Human
  • Soft Tissue Neoplasms / blood*
  • Soft Tissue Neoplasms / mortality
  • Soft Tissue Neoplasms / pathology*
  • Soft Tissue Neoplasms / therapy
  • Time Factors
  • Treatment Outcome
  • Young Adult

Substances

  • ALB protein, human
  • Biomarkers, Tumor
  • Serum Albumin
  • C-Reactive Protein
  • Serum Albumin, Human