Guideline for PET/CT imaging of neuroendocrine neoplasms with 68Ga-DOTA-conjugated somatostatin receptor targeting peptides and 18F-DOPA

Eur J Nucl Med Mol Imaging. 2017 Aug;44(9):1588-1601. doi: 10.1007/s00259-017-3728-y. Epub 2017 May 25.

Abstract

Purpose & methods: Neuroendocrine neoplasms are a heterogenous group of tumours, for which nuclear medicine plays an important role in the diagnostic work-up as well as in the targeted therapeutic options. This guideline is aimed to assist nuclear medicine physicians in recommending, performing, reporting and interpreting the results of somatostatin receptor (SSTR) PET/CT imaging using 68Ga-DOTA-conjugated peptides, as well as 18F-DOPA imaging for various neuroendocrine neoplasms.

Results & conclusion: The previous procedural guideline by EANM regarding the use PET/CT tumour imaging with 68Ga-conjugated peptides has been revised and updated with the relevant and recent literature in the field with contribution of distinguished experts.

Keywords: 18F–DOPA; 18F–FDG; 68Ga-DOTANOC; 68Ga-DOTATATE; 68Ga-DOTATOC; Foregut-NET; Hindgut-NET; Hyperinsulism in infants; Midgut-NET; Neuroendocrine neoplasms; Neuroendocrine tumours; Paraganglioma; Pet/Ct; Pheochromoacytoma; Thyroid medullary cancer.

MeSH terms

  • Dihydroxyphenylalanine / analogs & derivatives*
  • Gallium Radioisotopes*
  • Heterocyclic Compounds, 1-Ring / chemistry*
  • Humans
  • Image Interpretation, Computer-Assisted
  • Neuroendocrine Tumors / diagnostic imaging*
  • Peptides / chemistry
  • Peptides / metabolism*
  • Peptides / pharmacokinetics
  • Positron Emission Tomography Computed Tomography / methods*
  • Practice Guidelines as Topic
  • Quality Control
  • Receptors, Somatostatin / metabolism*
  • Tissue Distribution

Substances

  • Gallium Radioisotopes
  • Heterocyclic Compounds, 1-Ring
  • Peptides
  • Receptors, Somatostatin
  • 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
  • fluorodopa F 18
  • Dihydroxyphenylalanine
  • Gallium-68