Cavum septum pellucidum and first-episode psychosis: A meta-analysis

Hanwen Liu; Ling Li; Li Shen; Xianliang Wang; Yazhu Hou; Zhiqiang Zhao; Lili Gu; Jingyuan Mao

doi:10.1371/journal.pone.0177715

Cavum septum pellucidum and first-episode psychosis: A meta-analysis

PLoS One. 2017 May 17;12(5):e0177715. doi: 10.1371/journal.pone.0177715. eCollection 2017.

Authors

Hanwen Liu^{1

2}, Ling Li³, Li Shen⁴, Xianliang Wang⁵, Yazhu Hou⁵, Zhiqiang Zhao⁵, Lili Gu⁶, Jingyuan Mao²

Affiliations

¹ Tianjin University of Traditional Chinese Medicine, Tianjin, China.
² Internal Medicine Unit, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
³ Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
⁴ Department of Psychosomatic Medicine, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
⁵ Cardiovascular Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
⁶ Department of Medical Administration, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Abstract

Objectives: To investigate the prevalence and changes of cavum septum pellucidum (CSP) in first-episode psychosis (FEP) patients.

Methods: Medline, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched to identify eligible studies comparing FEP patients and healthy controls from inception to Feb 29, 2016.

Results: Ten cross-sectional studies and three longitudinal studies reported in ten articles met our criteria. Our meta-analysis found no significant differences in the prevalence of either "any CSP" (OR = 1.41; 95% CI 0.90-2.20; p = 0.13; I2 = 52.7%) or "large CSP" (OR = 1.10; 95% CI 0.77-1.58; p = 0.59; I2 = 24.1%) between FEP patients and healthy controls. However, the heterogeneity analysis of the prevalence of "any CSP" suggested bias in outcome reporting.

Conclusions: The results based on current evidence suggest it is unclear whether "any CSP" is a risk factor for FEP due to the heterogeneity of the studies. There is insufficient evidence to support that "large CSP" is a possible risk factor for FEP.

Publication types

Meta-Analysis

MeSH terms

Adult
Cross-Sectional Studies
Databases, Factual
Female
Humans
Magnetic Resonance Imaging
Male
Prevalence
Psychotic Disorders / diagnosis*
Psychotic Disorders / epidemiology
Septum Pellucidum / anatomy & histology
Septum Pellucidum / diagnostic imaging*
Septum Pellucidum / pathology
Sex Factors
Young Adult

Grants and funding

This project was supported by the Science and Technology Program of Tianjin (grant no. 15ZXLCSY00020). The content is solely the responsibility of the authors and does not necessarily represent the official views of the Science and Technology Program of Tianjin. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.