Primitive neuroectodermal tumor presenting as a delayed sequela to cranial irradiation and intrathecal methotrexate

E S Barasch; D Altieri; R E Decker; S Ahmed; J Lin

doi:10.1016/0887-8994(88)90087-2

Primitive neuroectodermal tumor presenting as a delayed sequela to cranial irradiation and intrathecal methotrexate

Pediatr Neurol. 1988 Nov-Dec;4(6):375-8. doi: 10.1016/0887-8994(88)90087-2.

Authors

E S Barasch¹, D Altieri, R E Decker, S Ahmed, J Lin

Affiliation

¹ Department of Neuroradiology, Albert Einstein College of Medicine, Bronx, New York.

PMID: 2854471
DOI: 10.1016/0887-8994(88)90087-2

Abstract

A patient developed a primitive neuroectodermal tumor (PNET) many years after therapeutic cerebral radiation and methotrexate treatment for leukemia. The differential radiologic and histologic diagnoses, as well as the possible co-oncogenic effects of radiation and methotrexate, are evaluated.

Publication types

Case Reports

MeSH terms

Adolescent
Brain Neoplasms / chemically induced
Brain Neoplasms / diagnostic imaging
Brain Neoplasms / etiology*
Brain Neoplasms / pathology
Female
Humans
Injections, Intraventricular
Methotrexate / administration & dosage
Methotrexate / adverse effects*
Neoplasms, Germ Cell and Embryonal / chemically induced
Neoplasms, Germ Cell and Embryonal / diagnostic imaging
Neoplasms, Germ Cell and Embryonal / etiology*
Neoplasms, Germ Cell and Embryonal / pathology
Neoplasms, Radiation-Induced / diagnostic imaging
Neoplasms, Radiation-Induced / pathology*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy*
Tomography, X-Ray Computed

Substances

Methotrexate