MITAP-compliant characterization of human regulatory macrophages

Transpl Int. 2017 Aug;30(8):765-775. doi: 10.1111/tri.12988. Epub 2017 Jun 26.

Abstract

This article provides a transparent description of Mreg_UKR cell products, including manufacture and quality-control processes, using the structure and vocabulary of the 'Minimum Information about Tolerogenic Antigen-presenting Cells' reporting guidelines. This information is intended as a resource for those in the field, as well as a stimulus to develop a new wave of immunoregulatory and tissue-reparative monocyte-derived cell therapies.

Keywords: Mreg; cell-based therapy; minimum information about tolerogenic antigen-presenting cells; monocyte; regulatory macrophage; solid organ transplantation; suppressor macrophage; tolerogenic antigen presenting cell (APC).

Publication types

  • Review

MeSH terms

  • Antigen-Presenting Cells / classification
  • Antigen-Presenting Cells / immunology
  • Blood Component Removal / methods
  • Cell Culture Techniques / methods
  • Cell Differentiation / immunology
  • Cell Separation / methods
  • Cell- and Tissue-Based Therapy / methods
  • Humans
  • Immunosuppression Therapy / methods
  • Kidney Transplantation
  • Living Donors
  • Macrophages / classification
  • Macrophages / immunology*
  • Monocytes / immunology
  • Transplantation Immunology
  • Transplantation Tolerance