Cytokine data obtained from synovial stromal cells of patients with rheumatoid arthritis or osteoarthritis

Johanna A Huhtakangas; Johanna Veijola; Sanna Turunen; Anna Karjalainen; Maarit Valkealahti; Tomi Nousiainen; Susanna Yli-Luukko; Olli Vuolteenaho; Petri Lehenkari

doi:10.1016/j.dib.2017.04.041

Cytokine data obtained from synovial stromal cells of patients with rheumatoid arthritis or osteoarthritis

Data Brief. 2017 Apr 29:12:593-602. doi: 10.1016/j.dib.2017.04.041. eCollection 2017 Jun.

Authors

Affiliations

¹ Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
² Rheumatology Unit, Department of Medicine, Oulu University Hospital and University of Oulu, Oulu, Finland.
³ Biochemistry and Molecular Medicine Research Unit, Medical Research Center Oulu, Oulu University, Oulu, Finland.
⁴ Division of Operative Care, Oulu University Hospital and University of Oulu, Oulu, Finland.
⁵ Biomedicine Unit, Department of Physiology, Medical Research Center Oulu, Oulu University, Oulu, Finland.

Abstract

In this article, we share the raw cytokine data obtained from basal and stimulated synovial stromal cells cultured from patients with rheumatoid arthritis or osteoarthritis. This data article is related to the research article entitled "1,25D₃ and calcipotriol, its hypocalcemic analog, exert a long-lasting anti-inflammatory and anti-proliferative effect in synoviocytes cultured from patients with rheumatoid arthritis and osteoarthritis (1). Cytokine levels were analyzed by a magnetic bead-based multiplex assay (a panel of 27 important cytokines) in two separate sets of experiments. The first was conducted with IL-1β and 1,25(OH)₂D₃ and the other with TNFα, calcipotriol, i.e. the hypocalcemic analog 1,25(OH)₂D₃, and dexamethasone. The raw data of this article display the individual variation in basal secretion of cytokines and in their response to different stimuli.

Keywords: Cytokines; Osteoarthritis; Rheumatoid arthritis.