Comparative effectiveness and impact on health-related quality of life of hysterectomy vs. levonorgestrel intra-uterine system for abnormal uterine bleeding

Eur Rev Med Pharmacol Sci. 2017 May;21(9):2255-2260.

Abstract

Objective: To compare hysterectomy and levonorgestrel intra-uterine system (LNG-IUS) for the treatment of abnormal uterine bleeding (AUB) and iron deficiency anemia.

Patients and methods: Retrospective study evaluating quality of life, sexual function, satisfaction and blood hemoglobin concentration improvement in 60 pre-menopausal women treated with hysterectomy or LNG-IUS. All analysis was performed with statistical software SPSS 21.0 (SPSS Inc., Chicago, IL, USA).

Results: Despite superior control of bleeding and dysmenorrhea observed after hysterectomy, LNG-IUS showed similar impact on blood hemoglobin levels, quality of life, satisfaction and sexual function resulting more cost-effective.

Conclusions: In the absence of contraindications, LNG-IUS should always be the first therapeutic choice for chronic AUB. Surgical treatment must be considered as an "extrema ratio".

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Female
  • Humans
  • Hysterectomy / psychology*
  • Intrauterine Devices, Medicated*
  • Levonorgestrel / administration & dosage*
  • Menorrhagia / drug therapy*
  • Middle Aged
  • Quality of Life*
  • Retrospective Studies

Substances

  • Levonorgestrel