Palladium-Catalyzed C(sp2)-H Acetoxylation via Electrochemical Oxidation

Yi-Qian Li; Qi-Liang Yang; Ping Fang; Tian-Sheng Mei; Dayong Zhang

doi:10.1021/acs.orglett.7b01138

Palladium-Catalyzed C(sp²)-H Acetoxylation via Electrochemical Oxidation

Org Lett. 2017 Jun 2;19(11):2905-2908. doi: 10.1021/acs.orglett.7b01138. Epub 2017 May 24.

Authors

Yi-Qian Li^{1

2}, Qi-Liang Yang², Ping Fang², Tian-Sheng Mei², Dayong Zhang¹

Affiliations

¹ Institute of Pharmaceutical Science, China Pharmaceutical University , Nanjing, P. R. China.
² State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, P. R. China.

PMID: 28537399
DOI: 10.1021/acs.orglett.7b01138

Abstract

Palladium-catalyzed arene C(sp²)-H acetoxylation has emerged as a powerful tool to construct a carbon-oxygen (C-O) bond. However, the requirement of stoichiometric chemical oxidants for this transformation possesses a significant disadvantage. To solve this fundamental problem, we now report an anodic oxidation strategy to achieve arene C(sp²)-H acetoxylation.

Publication types

Research Support, Non-U.S. Gov't