C21 steroidal glycosides from Cynanchum taihangense

Yu-Bo Wang; Shan-Shan Su; Shao-Fei Chen; Ming-Xu Tang; Gang Chen; Dan Zhao; Xia-Nan Sang; Ying-Ying Si; Hai-Feng Wang; Yue-Hu Pei

doi:10.1080/10286020.2017.1329302

C₂₁ steroidal glycosides from Cynanchum taihangense

J Asian Nat Prod Res. 2018 Mar;20(3):263-269. doi: 10.1080/10286020.2017.1329302. Epub 2017 May 24.

Authors

Yu-Bo Wang^{1

2

3}, Shan-Shan Su⁴, Shao-Fei Chen^{1

2}, Ming-Xu Tang^{1

2}, Gang Chen^{1

2}, Dan Zhao^{1

2}, Xia-Nan Sang^{1

2}, Ying-Ying Si^{1

2}, Hai-Feng Wang^{1

2}, Yue-Hu Pei^{1

2}

Affiliations

¹ a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , China.
² b Key Laboratory of Structure-Based Drug Design and Discovery , Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016 , China.
³ c School of Pharmacy, Jinzhou Medical University , Jinzhou 121001 , China.
⁴ d Testing Laboratory , Qinghai Entry-Exit Inspection and Quarantine Bureau , Xining 810000 , China.

PMID: 28537086
DOI: 10.1080/10286020.2017.1329302

Abstract

Two new C₂₁ steroidal glycosides, cynataihosides E (1) and F (2), together with a known one, sublanceoside H₂ (3), were isolated from Cynanchum taihangense. The aglycone of cynataihoside F (2) was also a new compound. Their structures were elucidated on the basis of NMR spectroscopic data, HR-ESI-MS analysis, and chemical evidence. Their cytotoxic activities against three human tumor cell lines (HL-60, THP1, and Caco2) were reported.

Keywords: Asclepiadaceae; Cynanchum taihangense; NMR data; cytotoxicity; deoxypyranoses; steroidal glycosides.

MeSH terms

Caco-2 Cells
Cynanchum / chemistry*
Glycosides / chemistry
Glycosides / isolation & purification*
Glycosides / pharmacology
HL-60 Cells
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Roots / chemistry
Steroids / chemistry
Steroids / isolation & purification*
Steroids / pharmacology

Substances

Glycosides
Steroids