Abstract
In this issue of JEM, Bergman et al. (https://doi.org/10.1084/jem.20160471) challenge the data published in our previous JEM paper on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Here, we provide a response to these data and suggest that appropriate subimmunogenic conditions are required to induce Foxp3+ regulatory T cell conversion.
© 2017 Daniel et al.
MeSH terms
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Animals
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Diabetes Mellitus, Type 1 / immunology*
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Diabetes Mellitus, Type 1 / prevention & control*
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Epitopes / immunology
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Everolimus / pharmacology
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Female
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Forkhead Transcription Factors / immunology
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Forkhead Transcription Factors / metabolism
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Gastrointestinal Microbiome / immunology
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Humans
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Immune Tolerance / immunology
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Immunosuppressive Agents / pharmacology
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Insulin / immunology*
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Mice, Inbred NOD
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T-Lymphocytes, Regulatory / drug effects
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T-Lymphocytes, Regulatory / metabolism
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TOR Serine-Threonine Kinases / antagonists & inhibitors
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TOR Serine-Threonine Kinases / immunology
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TOR Serine-Threonine Kinases / metabolism
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Vaccination / methods*
Substances
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Epitopes
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Forkhead Transcription Factors
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Foxp3 protein, mouse
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Immunosuppressive Agents
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Insulin
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Everolimus
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TOR Serine-Threonine Kinases