Homozygous transcription factor 3 gene (TCF3) mutation is associated with severe hypogammaglobulinemia and B-cell acute lymphoblastic leukemia

Affiliations

• ¹ Laboratory of Transmission, Control and Immunobiology of Infections (LR11IPT02), Institut Pasteur de Tunis, Tunis, Tunisia; Université Tunis El Manar, Tunis, Tunisia.
• ² Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China.
• ³ Department of Pediatrics, National Bone Marrow Transplantation Center, Tunis, Tunisia.
• ⁴ Department of Hematology, Aziza Othmana Hospital and University Tunis El Manar, Tunis, Tunisia.
• ⁵ Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China; Shenzhen Primary Immunodeficiency Diagnostic and Therapeutic Laboratory, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China. Electronic address: lauylung@hku.hk.
• ⁶ Laboratory of Transmission, Control and Immunobiology of Infections (LR11IPT02), Institut Pasteur de Tunis, Tunis, Tunisia; Université Tunis El Manar, Tunis, Tunisia. Electronic address: ridha.barbouche@pasteur.rns.tn.