Abstract
Quantitative control of histones and histone variants during cell cycle is relevant to their epigenetic functions. We found that the level of yeast histone variant H2A.Z in the G2/M-phase is actively kept low by the ubiquitin proteasome system and SUMO-targeted ubiquitin ligases. Overexpression of H2A.Z induced defects in mitotic progression, suggesting functional importance of this quantitative control.
Keywords:
H2A.Z; SUMO-targeted ubiquitin ligases; chromatin; histone.
MeSH terms
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DNA Helicases / genetics
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DNA Helicases / metabolism
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G2 Phase Cell Cycle Checkpoints
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Gene Expression Regulation, Fungal*
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Histones / genetics*
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Histones / metabolism
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Mitosis
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Proteasome Endopeptidase Complex / metabolism
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Proteolysis
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SUMO-1 Protein / genetics*
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SUMO-1 Protein / metabolism
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Saccharomyces cerevisiae / genetics*
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Saccharomyces cerevisiae / metabolism
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Saccharomyces cerevisiae Proteins / genetics*
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Saccharomyces cerevisiae Proteins / metabolism
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Ubiquitin / genetics*
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Ubiquitin / metabolism
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Ubiquitin-Protein Ligases / genetics
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Ubiquitin-Protein Ligases / metabolism
Substances
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Histones
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Htz1 protein, S cerevisiae
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SUMO-1 Protein
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Saccharomyces cerevisiae Proteins
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Ubiquitin
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Slx8 protein, S cerevisiae
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Ubiquitin-Protein Ligases
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Proteasome Endopeptidase Complex
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ULS1 protein, S cerevisiae
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DNA Helicases
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Slx5 protein, S cerevisiae