The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea

Mar Drugs. 2017 May 20;15(5):145. doi: 10.3390/md15050145.

Abstract

The marine cone snail Conus gloriamaris is an iconic species. For over two centuries, its shell was one of the most prized and valuable natural history objects in the world. Today, cone snails have attracted attention for their remarkable venom components. Many conotoxins are proving valuable as research tools, drug leads, and drugs. In this article, we present the venom gland transcriptome of C. gloriamaris, revealing this species' conotoxin repertoire. More than 100 conotoxin sequences were identified, representing a valuable resource for future drug discovery efforts.

Keywords: Conus; Conus gloriamaris; cone snail; conotoxin; venom.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Conotoxins / chemistry*
  • Conotoxins / pharmacology*
  • Conus Snail / physiology*
  • Mollusk Venoms / chemistry*
  • Mollusk Venoms / metabolism
  • Transcriptome

Substances

  • Conotoxins
  • Mollusk Venoms