The IGF axis in HPV associated cancers

Mutat Res Rev Mutat Res. 2017 Apr-Jun:772:67-77. doi: 10.1016/j.mrrev.2017.01.002. Epub 2017 Feb 4.

Abstract

Human papillomaviruses (HPV) infect and replicate in stratified epithelium at cutaneous and mucosal surfaces. The proliferation and maintenance of keratinocytes, the cells which make up this epithelium, are controlled by a number of growth factor receptors such as the keratinocyte growth factor receptor (KGFR, also called fibroblast growth factor receptor 2b (FGFR2b)), the epithelial growth factor receptor (EGFR) and the insulin-like growth factor receptors 1 and 2 (IGF1R and IGF2R). In this review, we will delineate the mutation, gene transcription, translation and processing of the IGF axis within HPV associated cancers. The IGFs are key for developmental and postnatal growth of almost all tissues; we explore whether this crucial axis has been hijacked by HPV.

Keywords: Cancer; HPV; IGF-I; IGF-II; IGF1R; IGF2R.

Publication types

  • Review

MeSH terms

  • Cell Proliferation
  • ErbB Receptors / genetics
  • ErbB Receptors / metabolism
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Keratinocytes / cytology
  • Keratinocytes / virology
  • Neoplasms / genetics*
  • Neoplasms / virology*
  • Papillomaviridae / pathogenicity*
  • Receptor, Fibroblast Growth Factor, Type 2 / genetics
  • Receptor, Fibroblast Growth Factor, Type 2 / metabolism
  • Receptor, IGF Type 1
  • Receptor, IGF Type 2 / genetics
  • Receptor, IGF Type 2 / metabolism
  • Receptors, Somatomedin / genetics
  • Receptors, Somatomedin / metabolism
  • Somatomedins / genetics*
  • Somatomedins / metabolism

Substances

  • IGF1R protein, human
  • Receptor, IGF Type 2
  • Receptors, Somatomedin
  • Somatomedins
  • EGFR protein, human
  • ErbB Receptors
  • FGFR2 protein, human
  • Receptor, Fibroblast Growth Factor, Type 2
  • Receptor, IGF Type 1