Surface design of magnetic nanoparticles for stimuli-responsive cancer imaging and therapy

Taegyu Kang; Fangyuan Li; Seungmin Baik; Wei Shao; Daishun Ling; Taeghwan Hyeon

doi:10.1016/j.biomaterials.2017.05.013

Surface design of magnetic nanoparticles for stimuli-responsive cancer imaging and therapy

Biomaterials. 2017 Aug:136:98-114. doi: 10.1016/j.biomaterials.2017.05.013. Epub 2017 May 8.

Authors

Taegyu Kang¹, Fangyuan Li², Seungmin Baik¹, Wei Shao², Daishun Ling³, Taeghwan Hyeon⁴

Affiliations

¹ Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea; School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.
² Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Key Laboratory of Biomedical Engineering of the Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, China.
³ Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Key Laboratory of Biomedical Engineering of the Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, China. Electronic address: lingds@zju.edu.cn.
⁴ Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea; School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: thyeon@snu.ac.kr.

PMID: 28525855
DOI: 10.1016/j.biomaterials.2017.05.013

Abstract

Magnetic nanoparticles (MNPs) have been extensively studied for their potential applications to cancer diagnosis and treatment. However, various obstacles limit the use of nanoparticles for delivery in the tumor microenvironment. As a viable solution to such obstacles, advances in nanoparticle surface engineering augmented by a profound understanding of cancer physiology present new opportunities for MNP-based imaging and therapeutic agents. Stimuli-responsive ligands, rationally designed to interact with various physicochemical aspects, can improve the performance of MNPs in cancer-targeted imaging and therapy. In this review, we highlight recent progress in the design of MNP-based stimuli-responsive nanomaterials and their applications to cancer diagnosis and treatment.

Keywords: Cancer imaging; Cancer therapy; Controlled release; Ligand; Magnetic nanoparticles; Stimuli-responsive.

Publication types

Review

MeSH terms

Animals
Delayed-Action Preparations / chemistry
Delayed-Action Preparations / therapeutic use
Humans
Magnetite Nanoparticles / chemistry*
Magnetite Nanoparticles / therapeutic use*
Nanomedicine / methods*
Nanotechnology / methods
Neoplasms / diagnosis*
Neoplasms / therapy*

Substances

Delayed-Action Preparations
Magnetite Nanoparticles