A dihydrochalcone derivative and further steroidal saponins from Sansevieria trifasciata Prain

Z Naturforsch C J Biosci. 2017 Oct 26;72(11-12):477-482. doi: 10.1515/znc-2017-0027.

Abstract

Phytochemical investigation of the aerial parts of Sansevieria trifasciata, one of the most common Dracaenaceae plants, has resulted in the isolation of a new dihydrochalcone derivative named trifasciatine C (1), four previously unreported steroidal saponins as two pairs of inseparable regioisomers: trifasciatosides K/L (2/3), M/N (4/5), together with the known 1,2-(dipalmitoyl)-3-O-β-D-galactopyranosylglycerol (6), aconitic acid (7), and 1-methyl aconitic acid (8). Their structures were elucidated mainly by extensive spectroscopic analysis (1D and 2D nuclear magnetic resonance) and high-resolution electronspray ionization-mass spectrometry, as well as chemical methods and comparison of their spectral data with those of related compounds. Compounds 2/3 and 4/5 were evaluated for their antiproliferative activity on Hela cells, and no significant effect was observed.

Keywords: Dracaenaceae; Sansevieria trifasciata; dihydrochalcone; steroidal saponins.

MeSH terms

  • Aconitic Acid / analogs & derivatives
  • Aconitic Acid / isolation & purification
  • Aconitic Acid / pharmacology
  • Carbohydrate Sequence
  • Cell Proliferation / drug effects
  • Chalcones / isolation & purification*
  • Chalcones / pharmacology
  • Galactosides / isolation & purification*
  • Galactosides / pharmacology
  • HeLa Cells
  • Humans
  • Sansevieria / chemistry*
  • Saponins / isolation & purification*
  • Saponins / pharmacology
  • Stereoisomerism

Substances

  • Chalcones
  • Galactosides
  • Saponins
  • Aconitic Acid
  • dihydrochalcone