Draft Genome Sequence of the Tacrolimus-Producing Bacterium Streptomyces tsukubaensis F601

Gongli Zong; Chuanqing Zhong; Jiafang Fu; Ronghuo Qin; Guangxiang Cao

doi:10.1128/genomeA.00385-17

Draft Genome Sequence of the Tacrolimus-Producing Bacterium Streptomyces tsukubaensis F601

Genome Announc. 2017 May 18;5(20):e00385-17. doi: 10.1128/genomeA.00385-17.

Authors

Gongli Zong¹, Chuanqing Zhong², Jiafang Fu¹, Ronghuo Qin¹, Guangxiang Cao³

Affiliations

¹ Shandong Academy of Medical Sciences, Shandong Medicinal Biotechnology Centre, Jinan, China.
² Shandong Jianzhu University, School of Municipal and Environmental Engineering, Jinan, China.
³ Shandong Academy of Medical Sciences, Shandong Medicinal Biotechnology Centre, Jinan, China caozhong0402@163.com.

Abstract

Streptomyces tsukubaensis strain F601 was found to be a producer of the immunosuppressive drug tacrolimus. The draft genome sequence of this strain was approximately 8.52 Mbp. Genes involved in the biosynthesis of tacrolimus were identified in the genome. This draft genome sequence will provide insights into the genetic basis of tacrolimus biosynthesis and regulation.