New Glycosides from the Fruits of Nicandra physaloides

Molecules. 2017 May 17;22(5):828. doi: 10.3390/molecules22050828.

Abstract

Three new glycosides (1-3) and 15 known ones (4-18) were isolated and identified from the fruits of Nicandra physaloides. The structures of these compounds were established by 1D and 2D NMR spectra and HR-ESI-MS. The compounds (4-18) were the first time isolated from the Nicandra genus and they (except 8, 10, 14) exhibited inhibitions on the NO release of LPS-induced RAW 264.7 cells with IC50 values from 26.9 to 47.5 μM.

Keywords: Nicandra physaloides; RAW 264.7; fat glycosides; inflammation; phenyl-glycosides.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Chromatography, Gas
  • Fruit / chemistry*
  • Glycosides / chemistry*
  • Glycosides / isolation & purification
  • Glycosides / pharmacology*
  • Hydrolysis
  • Macrophage Activation
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure
  • Nitric Oxide / metabolism
  • RAW 264.7 Cells
  • Solanaceae / chemistry*
  • Spectrometry, Mass, Electrospray Ionization

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Glycosides
  • Nitric Oxide