Abstract
A novel anthraquinone, 2-(dimethoxymethyl)-1-hydroxyanthracene-9,10-dione (1), together with nine known compounds (2-10), were isolated from the fermentation of Aspergillus versicolor derived from deep sea sediment. Their structures were established through spectroscopic methods. Compound 1 exhibited strong inhibitory activities against MRSA ATCC 43300 and MRSA CGMCC 1.12409 (with MIC values of 3.9 and 7.8 μg/mL respectively) and moderate activities against tested strains of Vibrio (with MIC values ranging from 15.6 to 62.5 μg/mL). Compound 1 was subjected to molecular docking studies for inhibition of topoisomerase IV and AmpC β-lactamase enzymes indicating its usefulness as antimicrobial agent.
Keywords:
Aspergillus versicolor; anthraquinone; antibacterial.
MeSH terms
-
Anthraquinones / chemistry*
-
Anti-Infective Agents / chemistry*
-
Anti-Infective Agents / pharmacology*
-
Aquatic Organisms
-
Aspergillus / chemistry*
-
Bacterial Proteins / antagonists & inhibitors
-
Bacterial Proteins / metabolism
-
DNA Topoisomerase IV / antagonists & inhibitors
-
Drug Evaluation, Preclinical
-
Fermentation
-
Geologic Sediments / microbiology
-
Methicillin-Resistant Staphylococcus aureus / drug effects
-
Microbial Sensitivity Tests
-
Molecular Docking Simulation
-
Molecular Structure
-
Topoisomerase Inhibitors / chemistry
-
Topoisomerase Inhibitors / pharmacology
-
Vibrio / drug effects
-
beta-Lactamases / metabolism
Substances
-
Anthraquinones
-
Anti-Infective Agents
-
Bacterial Proteins
-
Topoisomerase Inhibitors
-
AmpC beta-lactamases
-
beta-Lactamases
-
DNA Topoisomerase IV